ADME/DMPK Consultancy
Working closely with drug discovery and development teams across the biotech, CRO, pharmaceutical and academic sectors, Drug Discovery Solutions provides ADME/DMPK consultancy support and advice. We help clients all over the world progress new drugs to market.
Here at DDS, we can support project teams with one-off questions, multiple continuing requests or with on-going support embedded as part of the team – whatever works best for you and your project.
Human PK and Dose Prediction
We employ a variety of methods to predict human pharmacokinetic (PK) parameters depending on the compound properties. These include:
In vitro – in vivo extrapolation/correlation (IVIV-E/IVIV-C). Can we predict pre-clinical in vivo clearance from in vitro data?
Allometric scaling
Once we have predicted the human PK parameters, we can generate simulations of human plasma concentration-time profiles for a variety of dose levels/dose schedules, including predicting Cmax for safety margin prediction.
Design of a Target Candidate Profile and Screening Cascade
Here at DDS, we can help you design a target candidate profile alongside a screening cascade to help progression of molecules with desired properties. We place particular emphasis on referencing the Extended Clearance Classification System (ECCS) to ensure the most relevant assays are included, and we can help refine your screening cascade as your project progresses.
Project Review and Gap Analysis
Our team offer critical physicochemical and DMPK/ADME review of compounds at any stage of the drug discovery and development process, from hit to lead to short-listed late-stage compounds and candidate drugs. Our ADME/DMPK consultancy team help provide the answers to questions such as:
Does this compound have the potential to be a drug?
What parameters do I need to improve upon?
ADME/DMPK Protocol, Data and Report Review
With extensive hands-on experience, including designing, optimising and running PhysChem/DMPK studies, we are well placed to review data and recommend adjustments to best answer your projects questions.
We can also quality control check experimental data and provide critical review of written reports.
Drug Drug Interaction Assessment
We can provide expert interpretation and analysis of drug-drug interaction data – including calculation of risk.
Safety Margin Estimation
Our team can provide safety margin estimation based on initial dose range finding (DRF), maximum tolerated dose (MTD) study data or data from 28-day GLP toxicology studies. If you need a human dose/exposure prediction first, then we can help with that too.
Optimising Oral Bioavailability
