The Importance of Understanding Unbound Concentration
A must-read paper for anyone who is involved in the drug discovery process. One of the most referenced papers by DDS because it reinforces a key principle in modern DMPK.
Covalent Binders: When Understanding the Binding Kinetics is Crucial for Dose Prediction
This paper highlights the importance of kinetic parameters for understanding efficiency of inactivation.
Intestinal Extrusion: The Overlooked Pathway?
Direct intestinal excretion of drug from the blood to the intestinal mucosa is gaining more attention as a clearance pathway. Here we share an interesting review.